The aforementioned entourage effect is the main reason behind the efficacy of whole plant extracts. There are over 100 ‘identified’ compounds in the cannabis plant. While most of these compounds have their own therapeutic benefit, they combine synergistically to provide a far better performance than any single compound, including CBD. Here are a couple of examples of conditions that benefit from the entourage effect:

CBD Oil Full Spectrum


These studies conclude that “the higher efficiency of plant extract can be explained by additive or synergistic interactions between CBD, terpenes, and the minor phytocannabinoids or non-cannabinoids presented in the extracts. …because other phytocannabinoids, including Tetrahydrocannabivarin, Cannabigerol and Cannabichromene, as well as mono- and sesqui- terpenes, exert additional effects of therapeutic interest and the therapeutic synergy observed with plant extracts results in the requirement for a lower amount of active components, with consequent reduced adverse effects.”


Based on the comparison above, full spectrum hemp oil is more effective than CBD isolate, making it highly recommended for patients interested in holistic approaches to medicinal cannabis treatments. Hemp oil is an extremely potent source of CBD (responsible for a large bulk of the oil’s cannabinoid profile). To fully reap CBD oil benefits, one should explore the different mediums of the compound available on the market today.
A high quality brand of CBD will always provide third-party lab results to their consumers. Some laboratories finds favorable results, while some products fail these tests. These independent labs exist to ensure that CBD oil is everything it claims to be, with a high level of CBD, low THC, and lacking in impurities that can be harmful to consumers.

There’s a growing body of scientific evidence to support the use of topical CBD products to ease pain, inflammation, and the symptoms of arthritis. One study using rats found that topical CBD has “therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.” More scientific research on humans is needed to confirm all of CBD’s benefits, but the initial research into topical use in humans is also promising.

I suffer from **** from the military and the loss of my 17 year old son which was a very traumatic event and this CBD oil has help lesson my anxiety and stress. I feel I can function better and for the first time in years I can get a full night sleep. I used to lift weights and competed in bodybuilding for 10 years and this has actually helped my joints and mobility, at almost 50 years of age things don’t work like they used too but this CBD oil sure does help. Our dog has anxiety and hip issues and the pet tincture is a solid one-two punch for him and he can get up and down the stairs much better and doesn’t freak out as much when he is on it. You make an amazing product and I am glad I pulled the trigger on the order. I am ordering more and you have a loyal customer now, for me and my pets.


As shown in the chart above, each cannabinoid offers different benefits for a wide variety of ailments. Notably, CBD offers most of the benefits of each cannabinoid combined. While there is no debate that CBD offers the most benefits compared to any single cannabinoid, many wonder if CBD alone is more effective for treating ailments than all the cannabinoids combined.
The most abundant cannabinoid in hemp oil, making up over 90% of the cannabinoid content, cannabidiol or CBD is non-psychoactive and is the focus of the benefits from hemp oil. CBD has little affinity for CB1 or CB2 receptors, the main points of interaction for cannabinoids in the endocannabinoid system, and instead acts as an indirect antagonist of cannabinoid agonists, possibly allowing CBD to temper the high caused by THC. Our Gold Label RSHO™ is almost 25% CBD, making up most of oil’s weight. All other cannabinoids come in under 0.4% by weight.
It was previously believed that CBD in its isolated form was more potent and concentrated than full spectrum CBD; however, in 2015, the theory was debunked by a study from the Lautenberg Center for General Tumor Immunology in Jerusalem. In the study, researchers administered full spectrum CBD and CBD isolate to two different groups of mice. When comparing the data of the two groups, the results proved that the group administered with full spectrum CBD were provided with higher levels of relief. Furthermore, the study demonstrated that full spectrum CBD continued to provide relief as the dose increased, while CBD Isolate did not provide the same effect when there was an increase in dosage.
CBD is extracted from both plants in just the same way.  But, when it’s extracted from hemp, it is often times, extracted by itself.  Beyond CBD, there are a host of other plant compounds, called cannabinoids, present in both plants, including THC (more on THC later).  We won’t go into all the other compounds in this article as that would take a book to detail, but a short list of the most common ones are:  CBDA, CBG, CBGA, CBN, Terpenes and Phytonutrients, and THC.  Generally, when CBD is extracted from marijuana, all these compounds are extracted together and the extract is then formulated into various products, thus giving the user this “full spectrum” of cannabinoids.  Generally, when CBD is extracted from hemp, it may or may not include this full spectrum of cannabinoids.  So, this is the first important distinction between CBD from hemp and CBD from marijuana.  When it comes from hemp, it may or may not include all the other cannabinoids.  When it comes from marijuana, it almost always does, including the cannabinoid: THC.  (Note:  ALL Highland Pharms products use a full spectrum of cannabinoid extract.)
Many people are familiar with cannabidiol (CBD), which is found in highly concentrated amounts in our products, but there are actually dozens of cannabinoids found in hemp, which have shown many benefits in studies. We choose to make all our products with full-spectrum hemp oil, which includes all of the cannabinoids found in the plant, so you don’t miss out on any of the benefits.
Due to its non-psychoactive healing properties, Cannabidiol (CBD) has become a very popular option for patients seeking a natural alternative to treat conditions such as chronic pain, anxiety, epilepsy, and more. As patients start to understand how CBD can be used to alleviate their symptoms, they are often faced with a choice between using products made from CBD Isolate or Full Spectrum CBD. So, what exactly is the difference between the two?
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