The aforementioned entourage effect is the main reason behind the efficacy of whole plant extracts. There are over 100 ‘identified’ compounds in the cannabis plant. While most of these compounds have their own therapeutic benefit, they combine synergistically to provide a far better performance than any single compound, including CBD. Here are a couple of examples of conditions that benefit from the entourage effect:
I purchased Ananda professional full spectrum Extract 600 20/mg/ml CBD oil. I started with .5ml dose the first night right before bedtime. I did not sleep well. I tried the same dose the following evening, and again, poor sleep. I tried it for two more nights and had the same results. I’m very sensitive to steroids and will only use them as a last resort, but the way I felt after taking the CBD oil, reminded me of how poor my sleep is on steroids. Or how vitamin B12 can affect me if I take it too late in the day. I have a lot of inflammation and pain and hoped the CBD oil would help. I am quite surprised at my reaction to it. Anyone else have trouble sleeping when taking it?
While researchers are calling for more robust studies on the role of CBD on mood disorders, there is promising research that points to CBD’s role as an anxiolytic – which means it has anti-anxiety effects. Another study showed CBD to have antidepressant effects comparable to those of the prescription antidepressant Imipramine. We noted above that CBD increases levels of glutamate and serotonin – and it’s these same neurotransmitters that play a crucial role in mood regulation.
Tetrahydrocannabinol is the most abundant cannabinoid in most medical and recreational marijuana strains. However, in hemp THC is a minor constituent and appears only in trace amounts under 0.3% by dry weight, as required by the U.S. government for hemp products. THC mimics the action of anandamide, a neurotransmitter naturally produced in the human body, and binds to CB1 receptors in the endocannabinoid system found mostly in the brain. The extremely low levels of THC in hemp make hemp oil non-psychoactive and safe for all ages to use.
I am very pleased with the quality and the price of the high potency cbd. I have had my medical cannabis card for years and really became trusted with the high cost of my natural medicine, because the high costs and low cbd dosages found in the dispensaries. Now I can purchase high quality and high potency pure cbd oil at a great price without the worries of traveling with banned substances. Works better than xanax or antidepressants and no pharmaceutical side effects! I always take with my morning coffee and for pain and stress as needed. The only concern I have is with the shipping method as I would really benefit from USPS priority shipping instead of waiting for the long cross country ups ground, as the ups 3 day is very expensive. Besides the shipping options, I give this an A+! Thank you.
There is a lot of confusion out there. Both industrial hemp & marijuana are separate strains of the cannabis plant (hemp is c. sativa and marijuana can be either other strains of c. sativa or c. indica–marijuana has much, much more THC than hemp, which has little-to-none). The site is reviewing only CBD oils made from industrial hemp (more expensive from flower, cheaper & weaker from seeds & stalks) because those are the only kinds of CBD oil one can buy in all 50 states anywhere (not just licensed dispensaries), whether the state allows recreational weed, medical marijuana with an official cannabis ID card, or no marijuana whatsoever for any purpose.
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I’ve been taking the high potency tincture for a week and can’t believe how good it is. I tried several products purchased from my local CBD store and got no effect from them even when taking higher doses. I bought the high potency sample pack here and it fantastic. I just wish they had a vape product without PG/VG for quicker relief but until they do I’ll continue to purchase this product.
The health benefits of full-spectrum hemp go beyond it being a source of CBD. The array of cannabinoids and other natural constituents found in full-spectrum hemp oil work have been shown in studies to work together in what’s referred to as the “entourage effect.” Together, these compounds work harmoniously to magnify their therapeutic properties. The complex mix of cannabinoids, essential nutrients, protein, and healthy fats work synergistically to encourage homeostasis and balance in our health.
This is my 3rd time ordering. I’m still happy with this company. People are loving my tinctures and my balm I can hardly keep on the shelf. I have had a handful of customers ask me for a tincture without coconut oil though due to allergies. They don’t offer this in a tincture only in Isolate which I’m still not sure if it will work the same. So I’m hoping a coconut free version will be available sometime in the future.
It sounds like the title of a children’s book, but like so much else that you learned in kindergarten, it’s true. Everyone’s body is different – but everyone’s endocannabinoid system is really unique. For reasons we don’t fully understand, receptors in the endocannabinoid system don’t respond predictably to cannabinoids from person to person. This lack of a predictable response makes standard dosing tricky.
My bigger question is what about analytics ? So many bad lab’s out there in Cannabis and Hemp. Did they test for Pesticides ? Mycotoxins ? Heavy Metals (Hemp is great at dragging up heavy metals from the soil as well as from nutrient solutions, herbicides, etc..). The testing piece is critical and that a lab performs random testing to ensure that the final products on the shelf actually contain what’s on the label. Even good test results mean nothing if the product is cut after the testing.
CBD is extracted from both plants in just the same way.  But, when it’s extracted from hemp, it is often times, extracted by itself.  Beyond CBD, there are a host of other plant compounds, called cannabinoids, present in both plants, including THC (more on THC later).  We won’t go into all the other compounds in this article as that would take a book to detail, but a short list of the most common ones are:  CBDA, CBG, CBGA, CBN, Terpenes and Phytonutrients, and THC.  Generally, when CBD is extracted from marijuana, all these compounds are extracted together and the extract is then formulated into various products, thus giving the user this “full spectrum” of cannabinoids.  Generally, when CBD is extracted from hemp, it may or may not include this full spectrum of cannabinoids.  So, this is the first important distinction between CBD from hemp and CBD from marijuana.  When it comes from hemp, it may or may not include all the other cannabinoids.  When it comes from marijuana, it almost always does, including the cannabinoid: THC.  (Note:  ALL Highland Pharms products use a full spectrum of cannabinoid extract.)
Yes, CBD oils made from marijuana (sativa or indica) can have higher concentrations of both CBD–as well as CBN and THC (the latter is the “main attraction” because it’s psychoactive). But because not everyone can lawfully buy them (and those who can must purchase in person from a state-licensed dispensary) and they’re not available online except to customers living in certain recreational-weed-legal states, they aren’t being reviewed here. Also, MJ-derived CBD oils are not as widely produced and sold.

So a full spectrum decarb got higher points than isolate (“decarb” just refers to the process of decarboxylation which turns raw CBD into activated CBD). We also gave more points to companies with a “broad spectrum” tincture. Broad spectrum CBD oil includes a range of other cannabinoids, but minus the THC – which is generally what people using isolates are trying to avoid.

I’ve been taking the high potency tincture for a week and can’t believe how good it is. I tried several products purchased from my local CBD store and got no effect from them even when taking higher doses. I bought the high potency sample pack here and it fantastic. I just wish they had a vape product without PG/VG for quicker relief but until they do I’ll continue to purchase this product.

Thank you for a great product. I have been in constant pain for almost 17 years. It has helped relax my muscles so much better than what I can get prescribed by my doctors here. I am using Tylenol intermittently with it to space out the dosage. I haven’t noticed any side effects from it . This is my first time trying this and I am well pleased. Thank you again for this, it is a game changer for me.
I had bilateral partial knee replacements 3-5 years ago then scar tissue removal in my right knee. I have always had some pain and stiffness in the right knee since my last surgery, probable due to more scar tissue. I am not ready for more surgery yet. I am mostly on my feet for 12 hours at work. About a year ago the pain in my knee got so intense I was only able to sleep for only several hours a night even with an ice bag on my knee. I started shopping for CBD online. Tried several brands before finding Lazarus which is much better than the others at a better price. My pain is 90-95 % gone and I sleep like baby all night. Helps with anxiety. Thank you! Please don’t stop making a great product.
This product is perfect for anyone looking to find their daily dosage of CBD.  Our Full Spectrum Daily line of CBD products come in varying concentrations, from 250mg per bottle to 5,000mg per bottle. Everyone’s need for CBD is different, and this product line attempts to address this by allowing 1mL doses of CBD ranging in concentration from 7mg up to 84mg. If you’re not sure what your dosage of CBD is, it’s most common to introduce CBD slowly into your daily regimen and discover how CBD works for you! These oils are taken orally, just drop it into a spoon or directly into your mouth; these products are NOT designed to absorb under the tongue.
Cannabidiol is a plant compound extracted from cannabis (either marijuana or hemp) that is being reported by many to have positive effects on many conditions which have been requiring pharmaceutical solutions, such as cancer, diabetes, epilepsy, anxiety, TMJ, restless leg syndrome and so much more.  CBD extracts from marijuana typically have THC to some extent, thus causing some degree of ‘high’ and may or may not be legal where you live.  CBD extracts from hemp can either by CBD (singluarly) or in full spectrum cannabinoid blends.  Many people find relief with CBD in singular fashion, but best results are typically reported after taking CBD in full spectrum extracts.
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