While researchers are calling for more robust studies on the role of CBD on mood disorders, there is promising research that points to CBD’s role as an anxiolytic – which means it has anti-anxiety effects. Another study showed CBD to have antidepressant effects comparable to those of the prescription antidepressant Imipramine. We noted above that CBD increases levels of glutamate and serotonin – and it’s these same neurotransmitters that play a crucial role in mood regulation.
There are new CBD companies coming online every week – these span the range from truly awful to really great. So how to choose the best? The quality of the CBD oil itself is obviously the most important factor – and many companies do take the quality of their products seriously. To reward those companies, we gave more weight to the quality of the product than any other category.

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CBD is extracted from both plants in just the same way.  But, when it’s extracted from hemp, it is often times, extracted by itself.  Beyond CBD, there are a host of other plant compounds, called cannabinoids, present in both plants, including THC (more on THC later).  We won’t go into all the other compounds in this article as that would take a book to detail, but a short list of the most common ones are:  CBDA, CBG, CBGA, CBN, Terpenes and Phytonutrients, and THC.  Generally, when CBD is extracted from marijuana, all these compounds are extracted together and the extract is then formulated into various products, thus giving the user this “full spectrum” of cannabinoids.  Generally, when CBD is extracted from hemp, it may or may not include this full spectrum of cannabinoids.  So, this is the first important distinction between CBD from hemp and CBD from marijuana.  When it comes from hemp, it may or may not include all the other cannabinoids.  When it comes from marijuana, it almost always does, including the cannabinoid: THC.  (Note:  ALL Highland Pharms products use a full spectrum of cannabinoid extract.)
Yes, CBD oils made from marijuana (sativa or indica) can have higher concentrations of both CBD–as well as CBN and THC (the latter is the “main attraction” because it’s psychoactive). But because not everyone can lawfully buy them (and those who can must purchase in person from a state-licensed dispensary) and they’re not available online except to customers living in certain recreational-weed-legal states, they aren’t being reviewed here. Also, MJ-derived CBD oils are not as widely produced and sold.
CBD has become quite popular over the last couple of years but despite what you might think it is only one the 100 compounds that have been identified in the Cannabis Sativa L plant. Full spectrum CBD oil, unlike CBD isolate products, includes a wide range of cannabinoids present in the cannabis or hemp plant. Depending on the condition and what you are looking to achieve it can provide a greater effect than CBD alone as all the cannabinoids work together in what is known as the entourage effect (more on that later).
It sounds like the title of a children’s book, but like so much else that you learned in kindergarten, it’s true. Everyone’s body is different – but everyone’s endocannabinoid system is really unique. For reasons we don’t fully understand, receptors in the endocannabinoid system don’t respond predictably to cannabinoids from person to person. This lack of a predictable response makes standard dosing tricky.
There’s a growing body of scientific evidence to support the use of topical CBD products to ease pain, inflammation, and the symptoms of arthritis. One study using rats found that topical CBD has “therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.” More scientific research on humans is needed to confirm all of CBD’s benefits, but the initial research into topical use in humans is also promising.
Although low, the original amount of THC present in hemp may still cause a certain level of psychoactive effects when processed incorrectly. Remember, CBD oil is made from the extracts of hundreds, even thousands, of hemp plants, therefore, no matter how small a percentage of THC there is in hemp, it may still have a high concentration on CBD oils that have been processed poorly, especially since the equipment needed to properly process CBD oil from hemp can be costly.
While researchers are calling for more robust studies on the role of CBD on mood disorders, there is promising research that points to CBD’s role as an anxiolytic – which means it has anti-anxiety effects. Another study showed CBD to have antidepressant effects comparable to those of the prescription antidepressant Imipramine. We noted above that CBD increases levels of glutamate and serotonin – and it’s these same neurotransmitters that play a crucial role in mood regulation.
You may have read or heard in the news all the reports of people wanting to take CBD Oil for many ailments, some of which are cancer, epilepsy, chronic pain, TMJ, anxiety and diabetes.  And, many people are reporting some pretty fantastic improvements to their conditions after taking these oils.   The first thing most people want to know is: IS THERE ANY DIFFERENCE BETWEEN CANNABIDIOL FROM HEMP AND CANNABIDIOL FROM MARIJUANA?  And, the short answer is “no”; molecularly, CBD is CBD.  But, there are generally some differences in the CBD Extracts.  Let me explain this a bit further.
The health benefits of full-spectrum hemp go beyond it being a source of CBD. The array of cannabinoids and other natural constituents found in full-spectrum hemp oil work have been shown in studies to work together in what’s referred to as the “entourage effect.” Together, these compounds work harmoniously to magnify their therapeutic properties. The complex mix of cannabinoids, essential nutrients, protein, and healthy fats work synergistically to encourage homeostasis and balance in our health.
I wana take a minute to thank Lazarusnaturals for such great products. I have been suffering from ******,***** and ***** for years and have not been able to find relief from my pain medication,I know I’ll never be pain free as long as I’m breathing but CBD is pretty damn close to giving me my life back an being 90% pain free! I didn’t expect much from the CBD oil cuz there isn’t any THC (psychoactive) in it so I wasn’t getting excited lol but guess what?!! I’m super excited cuz this stuff works. Don’t knock it til you try it,if you suffer from pain do yourself a favor and order some CBD oil I promise you it will take the edge off.Im ordering my 3rd bottle now cuz this stuff works better then pain pills if you’re suffering from pain.

It sounds like the title of a children’s book, but like so much else that you learned in kindergarten, it’s true. Everyone’s body is different – but everyone’s endocannabinoid system is really unique. For reasons we don’t fully understand, receptors in the endocannabinoid system don’t respond predictably to cannabinoids from person to person. This lack of a predictable response makes standard dosing tricky.
It was previously believed that CBD in its isolated form was more potent and concentrated than full spectrum CBD; however, in 2015, the theory was debunked by a study from the Lautenberg Center for General Tumor Immunology in Jerusalem. In the study, researchers administered full spectrum CBD and CBD isolate to two different groups of mice. When comparing the data of the two groups, the results proved that the group administered with full spectrum CBD were provided with higher levels of relief. Furthermore, the study demonstrated that full spectrum CBD continued to provide relief as the dose increased, while CBD Isolate did not provide the same effect when there was an increase in dosage.
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