Also, I want to publicly express my sincere gratitude to “Lazarus Naturals” for being a socially responsible company and through its “assistance program” granting me a wonderful discount for its products and helping others as well who are on “fixed” monthly incomes. The savings will allow me to “pay it forward” and contribute small monthly donations to others who are financially disadvantaged. Kudos to “Lazarus Naturals” and “thank you” again.
As shown in the chart above, each cannabinoid offers different benefits for a wide variety of ailments. Notably, CBD offers most of the benefits of each cannabinoid combined. While there is no debate that CBD offers the most benefits compared to any single cannabinoid, many wonder if CBD alone is more effective for treating ailments than all the cannabinoids combined.
There’s a growing body of scientific evidence to support the use of topical CBD products to ease pain, inflammation, and the symptoms of arthritis. One study using rats found that topical CBD has “therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.” More scientific research on humans is needed to confirm all of CBD’s benefits, but the initial research into topical use in humans is also promising.
Another field in which CBD is creating a buzz is in the area of mood disorders like anxiety and depression. Both conditions have been treated with a variety of medications, courtesy of Big Pharma, that have had varying levels of success. Again, the long list of side effects can be off-putting to someone who just wants to get through the day without the sweaty tension of anxiety or the gray haze of depression.
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In short, Cannabidiol – or CBD – is a cannabis compound that has many therapeutic benefits. Usually extracted from the leaves and flowers of hemp plants – though marijuana can also be a source – CBD oil is then incorporated into an array of marketable products. These products vary from the most common, like sublingual oils and topical lotions, to the less common (think CBD lattes). Basically, if you can dream it, you can buy it.
CBD is extracted from both plants in just the same way. But, when it’s extracted from hemp, it is often times, extracted by itself. Beyond CBD, there are a host of other plant compounds, called cannabinoids, present in both plants, including THC (more on THC later). We won’t go into all the other compounds in this article as that would take a book to detail, but a short list of the most common ones are: CBDA, CBG, CBGA, CBN, Terpenes and Phytonutrients, and THC. Generally, when CBD is extracted from marijuana, all these compounds are extracted together and the extract is then formulated into various products, thus giving the user this “full spectrum” of cannabinoids. Generally, when CBD is extracted from hemp, it may or may not include this full spectrum of cannabinoids. So, this is the first important distinction between CBD from hemp and CBD from marijuana. When it comes from hemp, it may or may not include all the other cannabinoids. When it comes from marijuana, it almost always does, including the cannabinoid: THC. (Note: ALL Highland Pharms products use a full spectrum of cannabinoid extract.)
Full Spectrum generally refers to CBD oil products that not only contain CBD,but also contain some terpenes and other cannabinoids such as CBG, CBN and even some THC. Usually these will be in ratios that were naturally occurring and extracted from the plant and specific strain. But they are also occasionally added back into products as an isolated form to raise the potency of the product. For those that get drug tested, Full Spectrum is something to be cautious about. The THC found in full spectrum hemp products is minimal (less than 0.3%), but can still trigger positive drug tests.
Cannabinol results from the degradation of THC. There is little of it in the fresh plant, but decarboxylation often raises the amount of CBN in the plant as an effect. CBN is only mildly psychoactive and has a higher affinity for the CB2 receptor than the CB1 receptor, linking CBN to the body’s immune system. In hemp oil, CBN is present in levels of 0.2% or lower.
The most abundant cannabinoid in hemp oil, making up over 90% of the cannabinoid content, cannabidiol or CBD is non-psychoactive and is the focus of the benefits from hemp oil. CBD has little affinity for CB1 or CB2 receptors, the main points of interaction for cannabinoids in the endocannabinoid system, and instead acts as an indirect antagonist of cannabinoid agonists, possibly allowing CBD to temper the high caused by THC. Our Gold Label RSHO™ is almost 25% CBD, making up most of oil’s weight. All other cannabinoids come in under 0.4% by weight.
When CBD is in isolate form, it is separated from other cannabis compounds in the source plant. It was previously believed that CBD isolates were more potent and concentrated than full spectrum CBD. This assertion was eventually debunked by a study from the Lautenberg Center for General Tumor Immunology in Jerusalem. In the 2015 study, researchers were able to prove that full spectrum CBD is capable of offering greater levels of relief, as higher doses were administered to mice. By comparison, the group that was given CBD isolate did not experience the same level of relief at higher doses.
While researchers are calling for more robust studies on the role of CBD on mood disorders, there is promising research that points to CBD’s role as an anxiolytic – which means it has anti-anxiety effects. Another study showed CBD to have antidepressant effects comparable to those of the prescription antidepressant Imipramine. We noted above that CBD increases levels of glutamate and serotonin – and it’s these same neurotransmitters that play a crucial role in mood regulation.
It was previously believed that CBD in its isolated form was more potent and concentrated than full spectrum CBD; however, in 2015, the theory was debunked by a study from the Lautenberg Center for General Tumor Immunology in Jerusalem. In the study, researchers administered full spectrum CBD and CBD isolate to two different groups of mice. When comparing the data of the two groups, the results proved that the group administered with full spectrum CBD were provided with higher levels of relief. Furthermore, the study demonstrated that full spectrum CBD continued to provide relief as the dose increased, while CBD Isolate did not provide the same effect when there was an increase in dosage.