The aforementioned entourage effect is the main reason behind the efficacy of whole plant extracts. There are over 100 ‘identified’ compounds in the cannabis plant. While most of these compounds have their own therapeutic benefit, they combine synergistically to provide a far better performance than any single compound, including CBD. Here are a couple of examples of conditions that benefit from the entourage effect:
On a molecular level, all classes of cannabinoid are derived from the cannabinoid cannabigerol (CBG). Cannabinoids are changed from their original acid forms by decarboxylation through heat, light, or alkaline conditions, allowing them to interact fully with the endocannabinoid system. Learn more about all the cannabinoids found in our full spectrum hemp oil below:
So not only do our products include a variety of phytocompounds, each with their own health benefits*, but all of these compounds work together, building on their individual strengths to further heighten the body's positive response to CBD. Scientists named this process the “entourage effect,” which means that our whole-plant hemp extract provides more complete health benefits than taking CBD on its own.
It was previously believed that CBD in its isolated form was more potent and concentrated than full spectrum CBD; however, in 2015, the theory was debunked by a study from the Lautenberg Center for General Tumor Immunology in Jerusalem. In the study, researchers administered full spectrum CBD and CBD isolate to two different groups of mice. When comparing the data of the two groups, the results proved that the group administered with full spectrum CBD were provided with higher levels of relief. Furthermore, the study demonstrated that full spectrum CBD continued to provide relief as the dose increased, while CBD Isolate did not provide the same effect when there was an increase in dosage.
And now, onto the thorny issue of legality. The simple answer to the question is yes – if it is extracted from hemp. The 2014 Farm Bill established guidelines for growing hemp in the U.S. legally. This so-called  “industrial hemp” refers to both hemp and hemp products which come from cannabis plants with less than 0.3 percent THC and are grown by a state-licensed farmer.
Marijuana & hemp are both cannabis sativa (and some marijuana is cannabis indica). But “industrial hemp” (the only source of CBD lawful in all 50 states, thanks to the Federal Farm Bill’s exemption of it from the Controlled Substances Act) CBD extract products are lawful in all 50 states, can be sold on the open market at any store (not just a licensed dispensary) or online to anyone over 18–regardless of the customer’s or mfr’s state’s medical or recreational weed laws.

I can’t assist with what you need, but I can tell you that I am a cancer survivor ( 15 years), with Chronic Fibro, arthritis and nerve damage . I was on prescribed pain meds for a long time. CBD has been a life saver. I have tried several of the above. For me, Bluebird is the best so far of them all. In terms of effectiveness , its heads and tails ( no pun intended) above the rest. They do have a program as well , yes. They are pricey . I also like Lazarus’s 25 mg Capsules as well.

Do the right thing for your body and ensure that you only purchase high quality products from trusted sellers. Once you’ve decided between full spectrum vs regular CBD, you now need to make the choice of picking the right seller. Choose someone with a great reputation and independent lab testing results available on the site for all to see. You certainly want to make sure you get what you pay for! 


I can not recommend this highly enough, as well as Lazarus Naturals in general. This is theee best value on cbd I’ve seen, and it’s the most healthy because of the extraction process and the oils it’s diluted with. I would give 100 stars if I could. Thank you, Lazarus Naturals!!! And thank you for helping people with disabilities and low income such as myself. I am now a forever-loyal-customer!
We also rated the product based on the type of CBD they used: isolate, full-spectrum decarb, broad-spectrum, or distillate. There’s a lot of debate around what is actually best, but our first decision was to give points to CBD oil that contains a range of cannabinoids. While there are certainly people with good reasons for choosing an isolate, there’s a lot of good evidence that CBD works better in combination with other cannabinoids (this is called the “entourage effect”).
Based on the comparison above, full spectrum hemp oil is more effective than CBD isolate, making it highly recommended for patients interested in holistic approaches to medicinal cannabis treatments. Hemp oil is an extremely potent source of CBD (responsible for a large bulk of the oil’s cannabinoid profile). To fully reap CBD oil benefits, one should explore the different mediums of the compound available on the market today.
The most abundant cannabinoid in hemp oil, making up over 90% of the cannabinoid content, cannabidiol or CBD is non-psychoactive and is the focus of the benefits from hemp oil. CBD has little affinity for CB1 or CB2 receptors, the main points of interaction for cannabinoids in the endocannabinoid system, and instead acts as an indirect antagonist of cannabinoid agonists, possibly allowing CBD to temper the high caused by THC. Our Gold Label RSHO™ is almost 25% CBD, making up most of oil’s weight. All other cannabinoids come in under 0.4% by weight.
But there’s a big difference between the two. Hemp seed oil has been pressed from hemp seed, and it’s great for a lot of things – it’s good for you, tastes great, and can be used in soap, paint – even as biodiesel fuel. However, hemp seed oil does not contain any concentration of cannabinoids at all, including CBD. So by all means, stock up at your local natural food store. Just don’t expect to reap the benefits of a true CBD oil when you cook with hemp seed oil.
Tetrahydrocannabinol is the most abundant cannabinoid in most medical and recreational marijuana strains. However, in hemp THC is a minor constituent and appears only in trace amounts under 0.3% by dry weight, as required by the U.S. government for hemp products. THC mimics the action of anandamide, a neurotransmitter naturally produced in the human body, and binds to CB1 receptors in the endocannabinoid system found mostly in the brain. The extremely low levels of THC in hemp make hemp oil non-psychoactive and safe for all ages to use.

Being a hyperaccumulator also has drawbacks: If a hemp plant that is used in production of CBD oil was cultivated in a land that is rich in heavy metals such as mercury and lead, the resulting oils will also reflect the amount of heavy metals absorbed by the plant, making it unsafe for humans to consume, especially children or others who are extremely vulnerable to toxins.


It’s a truism to state that pain is an inevitable part of life. And it’s true that we all, from time to time, experience pain that is short-lived and treatable. But those who deal with chronic pain know the debilitating, life-sucking reality of this condition. And traditional medications often come with long lists of side effects which can be as debilitating as the pain itself.
You then take your first drop of CBD oil, wait 45 minutes, then ask the questions again. If you feel no different and there’s no change in the way you answer those questions, you increase the dose by small increments until you do notice a difference. You can continue this process over several days – and at some point, you’ll find that taking more doesn’t change your scores. That is your minimum effective dose.
Tetrahydrocannabinol is the most abundant cannabinoid in most medical and recreational marijuana strains. However, in hemp THC is a minor constituent and appears only in trace amounts under 0.3% by dry weight, as required by the U.S. government for hemp products. THC mimics the action of anandamide, a neurotransmitter naturally produced in the human body, and binds to CB1 receptors in the endocannabinoid system found mostly in the brain. The extremely low levels of THC in hemp make hemp oil non-psychoactive and safe for all ages to use.
Ingredients: 100 mg Hemp Flower Extract, Organic Coconut Oil, Organic Shea Butter, Cocoa Butter, Beeswax, Organic Menthol Crystals, Boswellia Extract Powder, White Willow Bark Extract, Organic Cayenne, Organic Calendula Flowers, Organic Ginger, Arnica Oil, Capsicum Oil, Sunflower Oil, Essential Oils: Wintergreen, Organic Eucalyptus, Peppermint, Lavender, and Ginger
The statements made regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Please consult your health care professional about potential interactions or other possible complications before using any product. The Federal Food, Drug and Cosmetic Act requires this notice.
We take an extra step. Using advanced chromatography, Calm Hemp Oil is free of THC, while retaining the full spectrum of cannabinoids, terpenes and flavonoids that create an entourage effect and may support full-body health. Calm hemp oil comes from premium non-GMO strains of hemp, organically grown in Colorado, USA and is 100% natural, with a refreshing mint taste.
The manufacturer will probably give you a recommended dosage, but bear in mind that this isn’t set in stone. What you need to find is your own minimum effective dose. “Minimum effective dose” is a medical term which refers to the amount of a substance you need for the results you want, and above which, the substance doesn’t increase in effectiveness.
I just wanted to say thank you. My 19 year old daughter has been suffering from chronic back pain since age 13. She has been to multiple doctors and chiropractors and has had MRIs and x-rays. Has been on multiple medications for pain and nothing was working. I decided to try purchase your high potency CBD oil as a last resort and to both of our astonishment for the first time she hasn’t had pain during the 2 weeks she has been taking it. I will be purchasing more of your product. Thank you so much.
THC is the plant compound that makes a person feel ‘high’.  It is naturally found in much higher quantities in marijuana, and in virtually non-existent quantities in hemp. So, when taking a full spectrum cannabinoid extract from hemp, the THC level is so low that you do not feel ‘high’ or groggy.  But, when taking CBD extracted from marijuana, even the “low CBD” strains typically have enough THC to cause someone to feel slightly ‘high’ or at least sleepy or groggy.  And, if its NOT a low CBD strain of marijuana, then watch out, you will most likely experience a pretty significant ‘high’.
I just received my second order of CBD oil ever and it defintely won’t be my last from Lazarus. After researching CBD oil brands to my heart’s content, I landed on Lazarus as it seems to be one of the top five best brands. That coupled with being the most economical led me to place my first CBD oil order with them. Their shipping to me (in Portland) the past two orders have always gotten here within two days, and I dig their product — although I don’t have anyting to compare it to. All in all, this is a five star company and you really can’t go wrong.
Thank you for a great product. I have been in constant pain for almost 17 years. It has helped relax my muscles so much better than what I can get prescribed by my doctors here. I am using Tylenol intermittently with it to space out the dosage. I haven’t noticed any side effects from it . This is my first time trying this and I am well pleased. Thank you again for this, it is a game changer for me.
Based on the comparison above, full spectrum hemp oil is more effective than CBD isolate, making it highly recommended for patients interested in holistic approaches to medicinal cannabis treatments. Hemp oil is an extremely potent source of CBD (responsible for a large bulk of the oil’s cannabinoid profile). To fully reap CBD oil benefits, one should explore the different mediums of the compound available on the market today.
As each Full Spectrum Hemp CBD Oil bottle comes with a precise dropper, it’s easy to exactly measure your serving size and adjust it according to your body’s needs. This also allows you to easily combine the Full Spectrum with any other CBD product to introduce more variety and enrich your daily CBD pleasure. You can try the Full Spectrum Hemp CBD Oil alongside any CBD edible or right before your CBD vape for a synergistic effect.
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