While researchers are calling for more robust studies on the role of CBD on mood disorders, there is promising research that points to CBD’s role as an anxiolytic – which means it has anti-anxiety effects. Another study showed CBD to have antidepressant effects comparable to those of the prescription antidepressant Imipramine. We noted above that CBD increases levels of glutamate and serotonin – and it’s these same neurotransmitters that play a crucial role in mood regulation.
Well For Starters,I Wanna Thank Lazarus for Honoring me and Giving me the Discount as A Qualification,And I Ordered the 6000 mg Bottle,I will Never Regret this,I can Take .25 ml and Be as Calm as a Cucumber,And Not Have to Take the Percocet Pain meds I was on,If Your Truly Asking Your Self Should I buy or not,I’m Gonna Say this,I’ve Bought Alot of Junk in my days,But this is The Real Deal,It Will Take good care of You,God Bless you Lazarus,Thank You For Taking Good Care of Us Veterans
We also rated the product based on the type of CBD they used: isolate, full-spectrum decarb, broad-spectrum, or distillate. There’s a lot of debate around what is actually best, but our first decision was to give points to CBD oil that contains a range of cannabinoids. While there are certainly people with good reasons for choosing an isolate, there’s a lot of good evidence that CBD works better in combination with other cannabinoids (this is called the “entourage effect”).
You then take your first drop of CBD oil, wait 45 minutes, then ask the questions again. If you feel no different and there’s no change in the way you answer those questions, you increase the dose by small increments until you do notice a difference. You can continue this process over several days – and at some point, you’ll find that taking more doesn’t change your scores. That is your minimum effective dose.
Isolate is typically the CBD oil product of choice for those who get drug tested or are sensitive to other cannabinoids such as THC. Products labeled as Isolate will generally be highlighted as being 99+% pure CBD. Usually, these products will have nothing but CBD in them because the CBD has literally been isolated from everything else. You can find pre-made isolate oils that typically consist of a carrier oil, such as MCT Oil, infused with the crystalline isolate powder. You can also find the “raw” crystalline powder or slabs (a form of concentrate) on its own.
There’s also been a lot of talk lately about “microdosing” CBD. This refers to an incremental process of finding your minimum effective dose. You can do this with any concentration of CBD oil, but lower concentrations will take longer. In a 2017 article in Rolling Stone, Dr. Dustan Sulak outlines his protocol for microdosing. You can begin this process by asking yourself three questions:

While researchers are calling for more robust studies on the role of CBD on mood disorders, there is promising research that points to CBD’s role as an anxiolytic – which means it has anti-anxiety effects. Another study showed CBD to have antidepressant effects comparable to those of the prescription antidepressant Imipramine. We noted above that CBD increases levels of glutamate and serotonin – and it’s these same neurotransmitters that play a crucial role in mood regulation.

Ordered this for my restless legs and it’s phenomenal, I have dropped the dosage down to about 6-7 drops a day (so about 15mg) and I have noticed a dramatic improvement in my sleep. I ordered my second small bottle and if the results remain constant I’ll be buying the 60ml next month! I have tried so many different things to help with sleep with no success or inconsistent results. I’m also a powerlifter and I’ve noticed a slight improvement in my recovery.


The manufacturer will probably give you a recommended dosage, but bear in mind that this isn’t set in stone. What you need to find is your own minimum effective dose. “Minimum effective dose” is a medical term which refers to the amount of a substance you need for the results you want, and above which, the substance doesn’t increase in effectiveness.
A high quality brand of CBD will always provide third-party lab results to their consumers. Some laboratories finds favorable results, while some products fail these tests. These independent labs exist to ensure that CBD oil is everything it claims to be, with a high level of CBD, low THC, and lacking in impurities that can be harmful to consumers.
This is my experience with taking CBD 3000mg for the last 6 months. My blood pressure has gone down, I am able to sleep better, the eczema on my hand has disappeared (using a drop or two twice a day on the area). Sort of did an assessment of my body/joints. Everything feels different in a good way. Joints seem to move smoother than before taking CBD. All is great here. Thanks, Lazarus Naturals for such great reasonably priced products.
When looking at isolate, it is important to verify the purity. While many are in the 99.9+% range with no identifiable amounts of THC, there are lower purity ones (such as 99.5% or lower) that may still have trace amounts that show up on the labs. This small amount is typically negligible, and is nowhere near the amount usually found in Full Spectrum products. But it’s still something to be aware of for those seeking the purest they can find.
I love this company and their amazing products! I have tried different CBD oils from 6 different companies, none of them came close to Lazarus Naturals. It was the first oil I tried and probably will be the one I continue to use for a very long time. This tincture helped me immensely! It gave me energy but also calmed my mind down as well. Another thing, their customer service is fantastic! I paid for express 2-day shipping on one of my previous orders but there was a miscommunication and it ended up being shipped standard and took a few more days then I expected. So I emailed them and they emailed me back the same day and refunded me the shipping costs. Overall, excellent high-quality products and amazing company! Thank you, guys!
There’s a growing body of scientific evidence to support the use of topical CBD products to ease pain, inflammation, and the symptoms of arthritis. One study using rats found that topical CBD has “therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.” More scientific research on humans is needed to confirm all of CBD’s benefits, but the initial research into topical use in humans is also promising.
There are new CBD companies coming online every week – these span the range from truly awful to really great. So how to choose the best? The quality of the CBD oil itself is obviously the most important factor – and many companies do take the quality of their products seriously. To reward those companies, we gave more weight to the quality of the product than any other category.

We also rated the product based on the type of CBD they used: isolate, full-spectrum decarb, broad-spectrum, or distillate. There’s a lot of debate around what is actually best, but our first decision was to give points to CBD oil that contains a range of cannabinoids. While there are certainly people with good reasons for choosing an isolate, there’s a lot of good evidence that CBD works better in combination with other cannabinoids (this is called the “entourage effect”).

Finally, in general, we almost always recommend full spectrum tinctures over supplements made from isolates (extracts of CBD alone). Full-spectrum or whole plant tinctures take advantage of the ‘entourage effect’ that comes from combining all the naturally occurring chemicals found in the hemp plant. Isolates are great for cooking with CBD or consumers that are especially sensitive to the taste of hemp extract, but some research suggests they may be less effective for certain uses than full spectrum extracts. All but two of the brands below are made from full spectrum hemp, and the exceptions are clearly noted.


I have been a smoker for 20 years. I smoked a pack and a half a day. The biggest problem I had with quitting was the anxiety I had from the withdrawals. I took one dose when it came in the mail this morning, and I haven’t even had a craving all day. My anxiety completely went away, and I’ve been in a great mood since I took it. Thank you for making a great product!!!!!!
I use plus CBD brand for my patients and myself.It’s a fantastic company with a great reliable product. They have the biggest share of retail outlets in the country so they have to be priced right and labeled properly. They also have GRAS rating. That means generally regarded as safe. They are the only CBD company to do the research and spend the money to get that rating. I love the gummies.
We take an extra step. Using advanced chromatography, Calm Hemp Oil is free of THC, while retaining the full spectrum of cannabinoids, terpenes and flavonoids that create an entourage effect and may support full-body health. Calm hemp oil comes from premium non-GMO strains of hemp, organically grown in Colorado, USA and is 100% natural, with a refreshing mint taste.
Received my first order about a month ago. Wanted to try it before giving feedback. I would frequently wake up at night with my hands just throbbing. I ordered the high potency tropical isolate. I have been taking a total of 60mg a day split into two doses. It has greatly reduced the pain in my hands, no longer waking up at night from the pain. I have also noticed it has a calming effect. Order was processed immediately and shipped right away with tracking. I am going to order the full spectrum when it is time for a refill as I can see it may work better for my needs. I would highly recommend LN and their products.

All I am seeing on this site is this brand is fantastic and that brand is fantastic! I don’t think I could trust any of these with the exception of one. I believe the only way to actually get good quality CBD is from a state licensed dispensary. Everyone else just wants to make a quick buck by jumping on the hype that it is now legal in all 50 states! I have cancer and herniated discs and fibromyalgia, asthma, PTSD, CFS severe anxiety, etc and will be starting radiation shortly. My pain right now is off the charts. I am afraid of most medications and pretty much will not take too many things. So when I get the CBD oil I will do it in front of a doctor to make sure of allergies. It will have to be of high quality and something that will not get me high! The fear of taking something from just any online distributor doesn’t ensure quality. If anyone out there can tell me with the most positive knowledge that a product is what it is then you can let me know. Any recommendations?

This may be a good place to point out that not all CBD products are created equal. The industry is still largely unregulated, and the quality and quantity of CBD in a given product will vary wildly. Third party testing definitely helps to monitor companies’ claims, but it’s still up to you as the consumer to do your homework on the best CBD products.

When looking at isolate, it is important to verify the purity. While many are in the 99.9+% range with no identifiable amounts of THC, there are lower purity ones (such as 99.5% or lower) that may still have trace amounts that show up on the labs. This small amount is typically negligible, and is nowhere near the amount usually found in Full Spectrum products. But it’s still something to be aware of for those seeking the purest they can find.
Thank you for a great product. I have been in constant pain for almost 17 years. It has helped relax my muscles so much better than what I can get prescribed by my doctors here. I am using Tylenol intermittently with it to space out the dosage. I haven’t noticed any side effects from it . This is my first time trying this and I am well pleased. Thank you again for this, it is a game changer for me.
Similarly, transparency is one of our top concerns when it comes to selecting the best CBD oil tinctures. Every product below is clearly labeled, so you can easily understand how much CBD oil / full spectrum hemp extract is in each bottle. You can also easily find the complete ingredients on the bottle, packaging or the company’s website. These brands are also open about where they source their hemp.
A high quality brand of CBD will always provide third-party lab results to their consumers. Some laboratories finds favorable results, while some products fail these tests. These independent labs exist to ensure that CBD oil is everything it claims to be, with a high level of CBD, low THC, and lacking in impurities that can be harmful to consumers.

Due to its non-psychoactive healing properties, Cannabidiol (CBD) has become a very popular option for patients seeking a natural alternative to treat conditions such as chronic pain, anxiety, epilepsy, and more. As patients start to understand how CBD can be used to alleviate their symptoms, they are often faced with a choice between using products made from CBD Isolate or Full Spectrum CBD. So, what exactly is the difference between the two?

×