On a molecular level, all classes of cannabinoid are derived from the cannabinoid cannabigerol (CBG). Cannabinoids are changed from their original acid forms by decarboxylation through heat, light, or alkaline conditions, allowing them to interact fully with the endocannabinoid system. Learn more about all the cannabinoids found in our full spectrum hemp oil below:
It was previously believed that CBD in its isolated form was more potent and concentrated than full spectrum CBD; however, in 2015, the theory was debunked by a study from the Lautenberg Center for General Tumor Immunology in Jerusalem. In the study, researchers administered full spectrum CBD and CBD isolate to two different groups of mice. When comparing the data of the two groups, the results proved that the group administered with full spectrum CBD were provided with higher levels of relief. Furthermore, the study demonstrated that full spectrum CBD continued to provide relief as the dose increased, while CBD Isolate did not provide the same effect when there was an increase in dosage.
CBD is extracted from both plants in just the same way. But, when it’s extracted from hemp, it is often times, extracted by itself. Beyond CBD, there are a host of other plant compounds, called cannabinoids, present in both plants, including THC (more on THC later). We won’t go into all the other compounds in this article as that would take a book to detail, but a short list of the most common ones are: CBDA, CBG, CBGA, CBN, Terpenes and Phytonutrients, and THC. Generally, when CBD is extracted from marijuana, all these compounds are extracted together and the extract is then formulated into various products, thus giving the user this “full spectrum” of cannabinoids. Generally, when CBD is extracted from hemp, it may or may not include this full spectrum of cannabinoids. So, this is the first important distinction between CBD from hemp and CBD from marijuana. When it comes from hemp, it may or may not include all the other cannabinoids. When it comes from marijuana, it almost always does, including the cannabinoid: THC. (Note: ALL Highland Pharms products use a full spectrum of cannabinoid extract.)
We also rated the product based on the type of CBD they used: isolate, full-spectrum decarb, broad-spectrum, or distillate. There’s a lot of debate around what is actually best, but our first decision was to give points to CBD oil that contains a range of cannabinoids. While there are certainly people with good reasons for choosing an isolate, there’s a lot of good evidence that CBD works better in combination with other cannabinoids (this is called the “entourage effect”).
I had bilateral partial knee replacements 3-5 years ago then scar tissue removal in my right knee. I have always had some pain and stiffness in the right knee since my last surgery, probable due to more scar tissue. I am not ready for more surgery yet. I am mostly on my feet for 12 hours at work. About a year ago the pain in my knee got so intense I was only able to sleep for only several hours a night even with an ice bag on my knee. I started shopping for CBD online. Tried several brands before finding Lazarus which is much better than the others at a better price. My pain is 90-95 % gone and I sleep like baby all night. Helps with anxiety. Thank you! Please don’t stop making a great product.
The aforementioned entourage effect is the main reason behind the efficacy of whole plant extracts. There are over 100 ‘identified’ compounds in the cannabis plant. While most of these compounds have their own therapeutic benefit, they combine synergistically to provide a far better performance than any single compound, including CBD. Here are a couple of examples of conditions that benefit from the entourage effect: